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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5803
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pubmed:dateCreated |
2006-11-24
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pubmed:abstractText |
Clostridium novyi-NT is an anaerobic bacterium that can infect hypoxic regions within experimental tumors. Because C. novyi-NT lyses red blood cells, we hypothesized that its membrane-disrupting properties could be exploited to enhance the release of liposome-encapsulated drugs within tumors. Here, we show that treatment of mice bearing large, established tumors with C. novyi-NT plus a single dose of liposomal doxorubicin often led to eradication of the tumors. The bacterial factor responsible for the enhanced drug release was identified as a previously unrecognized protein termed liposomase. This protein could potentially be incorporated into diverse experimental approaches for the specific delivery of chemotherapeutic agents to tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1308-11
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pubmed:dateRevised |
2010-2-25
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pubmed:meshHeading |
pubmed-meshheading:17124324-Amino Acid Sequence,
pubmed-meshheading:17124324-Animals,
pubmed-meshheading:17124324-Antineoplastic Agents,
pubmed-meshheading:17124324-Bacterial Proteins,
pubmed-meshheading:17124324-Base Sequence,
pubmed-meshheading:17124324-Camptothecin,
pubmed-meshheading:17124324-Cell Line, Tumor,
pubmed-meshheading:17124324-Cloning, Molecular,
pubmed-meshheading:17124324-Clostridium,
pubmed-meshheading:17124324-Colorectal Neoplasms,
pubmed-meshheading:17124324-Doxorubicin,
pubmed-meshheading:17124324-Drug Carriers,
pubmed-meshheading:17124324-Humans,
pubmed-meshheading:17124324-Lipase,
pubmed-meshheading:17124324-Lipid Bilayers,
pubmed-meshheading:17124324-Liposomes,
pubmed-meshheading:17124324-Mice,
pubmed-meshheading:17124324-Molecular Sequence Data,
pubmed-meshheading:17124324-Mutation,
pubmed-meshheading:17124324-Neoplasm Transplantation,
pubmed-meshheading:17124324-Protein Structure, Tertiary
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pubmed:year |
2006
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pubmed:articleTitle |
A bacterial protein enhances the release and efficacy of liposomal cancer drugs.
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pubmed:affiliation |
Howard Hughes Medical Institute and the Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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