|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-11-23
|
|
pubmed:abstractText |
We previously described an association between the -344C/T 5'-untranslated region (UTR) polymorphism in the CYP11B2 (aldosterone synthase) gene and hypertension with a raised aldosterone to renin ratio (ARR); the same genetic variant is also associated with impaired adrenal 11beta-hydroxylase efficiency. The -344 polymorphism does not seem to be functional, so is likely to be in linkage with variants in CYP11B1 that determine the associated variation in 11beta-hydroxylase efficiency. We therefore aimed to determine whether there is an association between CYP11B1 variants and hypertension and/or an altered ARR.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0300-0664
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
816-25
|
|
pubmed:dateRevised |
2007-7-13
|
|
pubmed:meshHeading |
pubmed-meshheading:17121536-Adolescent,
pubmed-meshheading:17121536-Adult,
pubmed-meshheading:17121536-Aged,
pubmed-meshheading:17121536-Aged, 80 and over,
pubmed-meshheading:17121536-Aldosterone,
pubmed-meshheading:17121536-Animals,
pubmed-meshheading:17121536-Biological Assay,
pubmed-meshheading:17121536-Case-Control Studies,
pubmed-meshheading:17121536-Corticosterone,
pubmed-meshheading:17121536-Cortodoxone,
pubmed-meshheading:17121536-Desoxycorticosterone,
pubmed-meshheading:17121536-Humans,
pubmed-meshheading:17121536-Hydrocortisone,
pubmed-meshheading:17121536-Hyperaldosteronism,
pubmed-meshheading:17121536-Hypertension,
pubmed-meshheading:17121536-Middle Aged,
pubmed-meshheading:17121536-Mutation, Missense,
pubmed-meshheading:17121536-Polymorphism, Single Nucleotide,
pubmed-meshheading:17121536-Rats,
pubmed-meshheading:17121536-Renin,
pubmed-meshheading:17121536-Sequence Analysis, DNA,
pubmed-meshheading:17121536-Steroid 11-beta-Hydroxylase
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene.
|
|
pubmed:affiliation |
Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
