Source:http://linkedlifedata.com/resource/pubmed/id/17119059
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2006-11-22
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| pubmed:abstractText |
Interleukin-6 (IL-6) promotes normal plasma cell development and proliferation of myeloma cells in culture. We evaluated IL-6 genotypes and body mass index (BMI) in a case-control study of multiple myeloma and plasmacytoma. DNA samples and questionnaires were obtained from incident cases of multiple myeloma (n = 134) and plasmacytoma (n = 16; plasma cell neoplasms) ascertained from the Los Angeles County population-based cancer registry and from siblings or cousins of cases (family controls, n = 112) and population controls (n = 126). Genotypes evaluated included IL-6 promoter gene single nucleotide polymorphisms (SNP) at positions -174, -572, and -597; one variable number of tandem repeats (-373 A(n)T(n)); and one SNP in the IL-6 receptor (IL-6ralpha) gene at position -358. The variant allele of the IL-6 promoter SNP -572 was associated with a roughly 2-fold increased risk of plasma cell neoplasms when cases were compared with family [odds ratio (OR), 1.8; 95% confidence interval (95% CI), 0.7-4.7] or population controls (OR, 2.4; 95% CI, 1.2-4.7). The -373 9A/9A genotype was associated with a decreased risk compared with the most common genotype (OR for cases versus family controls, 0.4; 95% CI, 0.1-1.7; OR for cases versus population controls, 0.3; 95% CI, 0.1-0.9). No other SNPs were associated with risk. Obesity (BMI >or= 30 kg/m(2)) increased risk nonsignificantly by 40% and 80% when cases were compared with family controls or population controls, respectively, relative to persons with a BMI of <25 kg/m(2). These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1055-9965
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| pubmed:author |
pubmed-author:BernsteinLeslieL,
pubmed-author:CoetzeeGerhard AGA,
pubmed-author:CoetzeeSimon GSG,
pubmed-author:ContiDavid VDV,
pubmed-author:CozenWendyW,
pubmed-author:GebregziabherMulugetaM,
pubmed-author:HartgePatriciaP,
pubmed-author:InglesSue ASA,
pubmed-author:MorhbacherAnnA,
pubmed-author:RothmanNathanielN,
pubmed-author:SalamMuhammad TMT,
pubmed-author:Van Den BergDavid JDJ,
pubmed-author:VighB JBJ,
pubmed-author:WangSophia SSS,
pubmed-author:ZadnickJohnJ
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| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2285-91
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17119059-Adult,
pubmed-meshheading:17119059-Aged,
pubmed-meshheading:17119059-Aged, 80 and over,
pubmed-meshheading:17119059-Body Mass Index,
pubmed-meshheading:17119059-Case-Control Studies,
pubmed-meshheading:17119059-Female,
pubmed-meshheading:17119059-Genetic Variation,
pubmed-meshheading:17119059-Genotype,
pubmed-meshheading:17119059-Humans,
pubmed-meshheading:17119059-Interleukin-6,
pubmed-meshheading:17119059-Male,
pubmed-meshheading:17119059-Middle Aged,
pubmed-meshheading:17119059-Multiple Myeloma,
pubmed-meshheading:17119059-Plasmacytoma,
pubmed-meshheading:17119059-Polymorphism, Single Nucleotide
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| pubmed:year |
2006
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| pubmed:articleTitle |
Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma.
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| pubmed:affiliation |
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089-9175, USA. wcozen@usc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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