Linked Life Data

17112806

Source:http://linkedlifedata.com/resource/pubmed/id/17112806

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pubmed-article:17112806pubmed:abstractTextAlfentanil is a short-acting synthetic opioid analgesic, which is extensively metabolized, mainly by hepatic cytochrome P450 (CYP) 3A enzymes. Concomitant administration of alfentanil and CYP3A inhibitors may lead to clinically important drug interactions. We investigated the possible interactions between alfentanil and orally administered voriconazole and terbinafine.lld:pubmed
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pubmed-article:17112806pubmed:articleTitleVoriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life.lld:pubmed
pubmed-article:17112806pubmed:affiliationDepartment of Anesthesiology and Intensive Care, University of Turku, Turku, Finland. teijo.saari@tyks.filld:pubmed
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pubmed-article:17112806pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:17112806pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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