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rdf:type |
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lifeskim:mentions |
umls-concept:C0003342,
umls-concept:C0036588,
umls-concept:C0039194,
umls-concept:C0392337,
umls-concept:C0442821,
umls-concept:C0600364,
umls-concept:C0871261,
umls-concept:C1258084,
umls-concept:C1335376,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
45
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pubmed:dateCreated |
2006-11-8
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pubmed:abstractText |
Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To elucidate the molecular recognition events on live CTL, we have utilized a self-assembled biosensor composed of semiconductor nanocrystals, quantum dots, carrying a controlled number of virus-derived (cognate) and other (noncognate) pMHC-I complexes and examined their recognition by antigen-specific T cell receptor (TCR) on anti-virus CD8(+) T cells. The unique architecture of nanoscale quantum dot/pMHC-I conjugates revealed that unexpectedly strong multivalent CD8-MHC-I interactions underlie the cooperative contribution of noncognate pMHC-I to the recognition of cognate pMHC-I by TCR to augment T cell responses. The cooperative, CD8-dependent spread of signal from a few productively engaged TCR to many other TCR can explain the remarkable ability of CTL to respond to virus-infected cells that present few cognate pMHC-I complexes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-10072074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-10202928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-10809759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-10835691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11106664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11114424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11172018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11248809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11384988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11423406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-11790533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12133804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12213345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12397360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12475334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12594952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12705834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12799041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-12942071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-14702108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-14709096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15247914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15554924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15669863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15724150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15805102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15869297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15886114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15928695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-15980863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-1722325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-7513441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-7523570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-8144921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-8666949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-8673703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17077145-9990061
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16846-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17077145-Antigens, CD8,
pubmed-meshheading:17077145-Antigens, Viral,
pubmed-meshheading:17077145-Autoantigens,
pubmed-meshheading:17077145-Biosensing Techniques,
pubmed-meshheading:17077145-Clone Cells,
pubmed-meshheading:17077145-HLA-A2 Antigen,
pubmed-meshheading:17077145-Humans,
pubmed-meshheading:17077145-Lymphocyte Activation,
pubmed-meshheading:17077145-Models, Immunological,
pubmed-meshheading:17077145-Quantum Dots,
pubmed-meshheading:17077145-Receptors, Antigen, T-Cell,
pubmed-meshheading:17077145-Signal Transduction,
pubmed-meshheading:17077145-T-Lymphocytes, Cytotoxic
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pubmed:year |
2006
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pubmed:articleTitle |
Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.
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pubmed:affiliation |
Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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