Source:http://linkedlifedata.com/resource/pubmed/id/17074054
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2006-10-31
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| pubmed:abstractText |
Accumulating evidence has suggested that brain-derived neurotrophic factor (BDNF) plays a role in eating behaviours, and that BDNF-heterozygous (+/-) mice exhibit abnormal behaviours (e.g. obesity, anxiety and aggression). The present study was undertaken to determine whether or not dietary restriction (DR) alters the behaviours in BDNF(+/-) mice, as DR has been shown to exert a number of beneficial effects on the brain. Eight-week-old male wild-type (+/+) and BDNF(+/-) mice were divided into two groups, ad libitum (AL) diet group and DR group, for 16 weeks. After carrying out a behavioural evaluation, we determined the BDNF mRNA levels, as well as mRNA levels for subtypes (5-HT(1A), 5-HT(1B), 5-HT(2A) and 5-HT(2C)) of the 5-HT receptor and 5-HT transporter (5-HTT), protein levels of BDNF and concentrations of 5-HT and 5-HIAA in the hypothalamus, hippocampus and frontal cortex. DR significantly ameliorated behaviours including obesity, anxiety and aggression in BDNF(+/-) mice. The concentrations of 5-HT and 5-HIAA in the frontal cortex, and 5-HT in the hippocampus, of BDNF(+/-) mice were significantly lower than those of wild-type mice. Interestingly, DR significantly increased the levels of 5-HT and 5-HIAA in the frontal cortex of BDNF(+/-) mice. These findings suggest that DR may alter the behaviours in BDNF(+/-) mice, and that the 5-HT system may be implicated in the beneficial effects of DR on these behaviours.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0953-816X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2335-44
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| pubmed:meshHeading |
pubmed-meshheading:17074054-Aggression,
pubmed-meshheading:17074054-Animals,
pubmed-meshheading:17074054-Anxiety,
pubmed-meshheading:17074054-Behavior, Animal,
pubmed-meshheading:17074054-Body Weight,
pubmed-meshheading:17074054-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:17074054-Chromatography, High Pressure Liquid,
pubmed-meshheading:17074054-Data Interpretation, Statistical,
pubmed-meshheading:17074054-Eating,
pubmed-meshheading:17074054-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17074054-Exploratory Behavior,
pubmed-meshheading:17074054-Food Deprivation,
pubmed-meshheading:17074054-Heterozygote,
pubmed-meshheading:17074054-Hydroxyindoleacetic Acid,
pubmed-meshheading:17074054-Mice,
pubmed-meshheading:17074054-Mice, Inbred C57BL,
pubmed-meshheading:17074054-Mice, Knockout,
pubmed-meshheading:17074054-Obesity,
pubmed-meshheading:17074054-RNA, Messenger,
pubmed-meshheading:17074054-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17074054-Serotonin
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Dietary restriction changes behaviours in brain-derived neurotrophic factor heterozygous mice: role of serotonergic system.
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| pubmed:affiliation |
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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