| pubmed-article:17045823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0237519 | lld:lifeskim |
| pubmed-article:17045823 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:17045823 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:17045823 | pubmed:dateCreated | 2006-10-18 | lld:pubmed |
| pubmed-article:17045823 | pubmed:abstractText | Casitas B cell lymphoma (Cbl) proteins are negative regulators for T cell antigen receptor (TCR) signaling. Their role in thymocyte development remains unclear. Here we show that simultaneous inactivation of c-Cbl and Cbl-b in thymocytes enhanced thymic negative selection and altered the ratio of CD4(+) and CD8(+) T cells. Strikingly, the mutant thymocytes developed into CD4(+)- and CD8(+)-lineage T cells independent of the major histocompatibility complex (MHC), indicating that the CD4(+)- and CD8(+)-lineage development programs are constitutively active in the absence of c-Cbl and Cbl-b. The mutant double-positive (DP) thymocytes exhibited spontaneous hyperactivation of nuclear factor-kappa B (NF-kappaB). Additionally, they failed to downregulate the pre-TCR and pre-TCR signaling. Thus, our data indicate that Cbl proteins play a critical role in establishing the MHC-dependent CD4(+) and CD8(+) T cell development programs. They likely do so by suppressing MHC-independent NF-kappaB activation, possibly through downmodulating pre-TCR signaling in DP thymocytes. | lld:pubmed |
| pubmed-article:17045823 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17045823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17045823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17045823 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17045823 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:HuangFangF | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:GuHuaH | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:KitauraYasuyu... | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:NaramuraMayum... | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:SchlisselMark... | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:LiuLipingL | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:QinHaiyanH | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:JangIhnkyungI | lld:pubmed |
| pubmed-article:17045823 | pubmed:author | pubmed-author:KoleHemanta... | lld:pubmed |
| pubmed-article:17045823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17045823 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:17045823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17045823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17045823 | pubmed:pagination | 571-81 | lld:pubmed |
| pubmed-article:17045823 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:meshHeading | pubmed-meshheading:17045823... | lld:pubmed |
| pubmed-article:17045823 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17045823 | pubmed:articleTitle | Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. | lld:pubmed |
| pubmed-article:17045823 | pubmed:affiliation | Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA. | lld:pubmed |
| pubmed-article:17045823 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17045823 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17045823 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:17045823 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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