Linked Life Data

16982741

Source:http://linkedlifedata.com/resource/pubmed/id/16982741

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16982741rdf:typepubmed:Citationlld:pubmed
pubmed-article:16982741lifeskim:mentionsumls-concept:C0024299lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0007634lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0206180lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0054950lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0441889lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C1456796lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C1705984lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0851285lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:16982741lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:16982741pubmed:issue18lld:pubmed
pubmed-article:16982741pubmed:dateCreated2006-9-19lld:pubmed
pubmed-article:16982741pubmed:abstractTextChromosomal translocation t(2;5) and the resulting fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) are detected in 50% to 70% of anaplastic large cell lymphoma (ALCL), which is a T/null cell non-Hodgkin's lymphoma showing anaplastic morphology with cell surface expression of CD30. Because aberrant CD30 expression was also observed in the T-cell lymphoma derived from lineage-specific NPM-ALK transgenic mice, we tested the hypothesis that there might be a functional relationship between the two neoplastic-related proteins: NPM-ALK and CD30. In this study, we used the RNA interference method to modulate NPM-ALK protein expression in ALCL-derived, t(2;5)-positive Karpas 299 cells. We observed decreased CD30 expression when NPM-ALK was repressed. Further analysis suggested that JunB functioned as the mediator of NPM-ALK-derived CD30 transcriptional regulation. The NPM-ALK-repressed cells, which had low CD30 expression, were characterized with lower cell proliferation compared with cells in the control group, suggesting that altered CD30 expression may correlate to NPM-ALK-mediated tumor cell growth inhibition. Combination of NPM-ALK repression and CD30 ligand leads to significantly increased tumor cell growth inhibition compared with one method alone, suggesting its potential application for ALCL-specific cancer treatment.lld:pubmed
pubmed-article:16982741pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:languageenglld:pubmed
pubmed-article:16982741pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:citationSubsetIMlld:pubmed
pubmed-article:16982741pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16982741pubmed:statusMEDLINElld:pubmed
pubmed-article:16982741pubmed:monthSeplld:pubmed
pubmed-article:16982741pubmed:issn0008-5472lld:pubmed
pubmed-article:16982741pubmed:authorpubmed-author:ZhaoYiYlld:pubmed
pubmed-article:16982741pubmed:authorpubmed-author:JohnstonPatri...lld:pubmed
pubmed-article:16982741pubmed:authorpubmed-author:BurkeKathleen...lld:pubmed
pubmed-article:16982741pubmed:authorpubmed-author:HsuFaye...lld:pubmed
pubmed-article:16982741pubmed:issnTypePrintlld:pubmed
pubmed-article:16982741pubmed:day15lld:pubmed
pubmed-article:16982741pubmed:volume66lld:pubmed
pubmed-article:16982741pubmed:ownerNLMlld:pubmed
pubmed-article:16982741pubmed:authorsCompleteYlld:pubmed
pubmed-article:16982741pubmed:pagination9002-8lld:pubmed
pubmed-article:16982741pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:meshHeadingpubmed-meshheading:16982741...lld:pubmed
pubmed-article:16982741pubmed:year2006lld:pubmed
pubmed-article:16982741pubmed:articleTitleThe expression of CD30 in anaplastic large cell lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner.lld:pubmed
pubmed-article:16982741pubmed:affiliationDepartment of Biochemistry, Norris Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.lld:pubmed
pubmed-article:16982741pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16982741pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16982741lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16982741lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16982741lld:pubmed