| pubmed-article:16981010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0035804 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0015677 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0005495 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16981010 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16981010 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:16981010 | pubmed:dateCreated | 2006-10-3 | lld:pubmed |
| pubmed-article:16981010 | pubmed:abstractText | Obesity is associated with chronic low-grade inflammation. Thus, at metabolically relevant sites, including adipose tissue and muscle, there is abnormal production of proinflammatory cytokines such as TNF-alpha. Here we demonstrate that eNOS expression was reduced, with a concomitant reduction of mitochondrial biogenesis and function, in white and brown adipose tissue and in the soleus muscle of 3 different animal models of obesity. The genetic deletion of TNF receptor 1 in obese mice restored eNOS expression and mitochondrial biogenesis in fat and muscle; this was associated with less body weight gain than in obese wild-type controls. Furthermore, TNF-alpha downregulated eNOS expression and mitochondrial biogenesis in cultured white and brown adipocytes and muscle satellite cells of mice. The NO donors DETA-NO and SNAP prevented the reduction of mitochondrial biogenesis observed with TNF-alpha. Our findings demonstrate that TNF-alpha impairs mitochondrial biogenesis and function in different tissues of obese rodents by downregulating eNOS expression and suggest a novel pathophysiological process that sustains obesity. | lld:pubmed |
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| pubmed-article:16981010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16981010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16981010 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16981010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16981010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16981010 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:16981010 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:MoncadaSalvad... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:CantoniOrazio... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:CozziValeriaV | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:CarrubaMichel... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:NisoliEnzoE | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:ClementiEmili... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:ValerioAlessa... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:PiscontiAddol... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:PalombaLetizi... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:BracaleRenata... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:CardileAnnali... | lld:pubmed |
| pubmed-article:16981010 | pubmed:author | pubmed-author:TedescoLauraL | lld:pubmed |
| pubmed-article:16981010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16981010 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:16981010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16981010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16981010 | pubmed:pagination | 2791-8 | lld:pubmed |
