Linked Life Data

16971349

Source:http://linkedlifedata.com/resource/pubmed/id/16971349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-9-14
pubmed:abstractText
Muscle abnormalities involved in chronic obstructive pulmonary disease (COPD) or the changes leading to muscle wasting and cachexia in neoplastic patients have a remarkable clinical impact, but their study is complex and findings are sometimes paradoxical. In this review, the main factors influencing muscle wasting and muscle abnormalities found in chronic diseases such as COPD are regarded in the light of a comprehensive approach. All this changes work in a complex, multifactorial manner, and experimental or observational approaches must take this fact into consideration. Two concepts that may be helpful in this regard are the "muscle compartment theory," by which different muscle groups, individual muscles, or muscle areas may react differently to a variety of stimuli and pathogenic factors, and the "oil well analogy," which reflects the complexity and variability of the energy resource depletion mechanisms in cells and tissues, leading to structural remodeling and functional adaptation or impairment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1521-0758
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-52
pubmed:dateRevised
2009-6-26
pubmed:meshHeading
pubmed:articleTitle
The "oil well analogy" as a comprehensive interpretation of factors leading to muscle injury and wasting.
pubmed:affiliation
Muscle and Respiratory System Research Unit URMAR, Municipal Institute of Medical Research IMIM, Respiratory Medicine Department, Hospital del Mar, CEXS, Universitat Pompeu Fabra, Barcelona, Spain. morozco@imim.es
pubmed:publicationType
Journal Article, Review