Linked Life Data

16971153

Source:http://linkedlifedata.com/resource/pubmed/id/16971153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2006-10-18
pubmed:abstractText
Estrogens are classically known to play a major role in female reproduction but there is now compelling evidence that they may also be involved in the regulation of male reproductive function. In humans, a decrease in sperm count and an increase in the incidences of testicular cancer, cryptorchidism and hypospadia have been observed in many countries over the last 50 years. Male reproductive alterations were also observed in wildlife. Such male reproductive disorders have been attributed to the increase in concentration of xenobiotics, and of xenoestrogens in particular, in the environment and in food. Epidemiological, clinical and experimental studies have suggested that excessive exposure to estrogens during fetal/neonatal life can lead to reproductive disorders in adulthood. Using an in vitro model we showed that estrogens directly affected the development of the fetal testis and we evidenced the existence of periods of sensitivity throughout development. Lastly, we clearly demonstrated that the fetal and neonatal testis is very sensitive to estrogens since the invalidation of estrogen receptor alpha leads to an increase of steroidogenesis and the invalidation of estrogen receptor beta enhances the development of the germ cell lineage in the male.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1297-9589
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
970-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Effects of estrogens on the development of the testis during fetal and neonatal life].
pubmed:affiliation
Unité mixte de recherche sur la gamétogenèse et la génotoxicité, Inserm U566, CEA, université Paris-VII, Equipe différenciation et radiobiologie des gonades, CEA-DSV-DRR/SEGG-LDRG, 92265 Fontenay-aux-Roses, France. rene.habert@cea.fr
pubmed:publicationType
Journal Article, English Abstract, Review