| pubmed-article:1696655 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0003842 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0042449 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0521454 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0012373 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0028066 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1696655 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:1696655 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1696655 | pubmed:dateCreated | 1990-9-18 | lld:pubmed |
| pubmed-article:1696655 | pubmed:abstractText | 5-Hydroxytryptamine (5-HT) and K+ induced contractions in human chorionic arteries and veins. 5-HT-caused responses were blocked by ketanserin (10(-7) and 10(-6) M) and prazosin (10(-5) but not 10(-6) M). K(+)-induced contractions were practically abolished in a Ca2(+)-free medium, whereas those produced by 5-HT were reduced. The efficacy (EC50 values) of diltiazem to produce relaxation in arteries and veins contracted with 40 or 75 mM K+ was similar, but normally greater than that of nifedipine. The potency of nifedipine (IC50 values) to inhibit maximal K+ contractions was greater than to inhibit maximal 5-HT contractions; diltiazem showed an inverse order of potency, which was less than that of nifedipine. The time course of 10(-6) M 5-HT and 75 mM K+ contractions was different, as much in the absence as in the presence of both Ca2+ antagonists; 5-HT contractions were transient, but sustained those elicited by K+. K+ (75 mM) and 5-HT (10(-6) M) produced increases in 45Ca2+ uptake, which were reduced by the Ca2+ antagonists. These results indicate that (a) human chorionic arteries and veins are similarly sensitive to Ca2+ antagonists, (b) 5-HT-induced contractions were largely dependent on extracellular Ca2+ and mainly mediated by 5-HT2 receptors but not by alpha 1-adrenoceptors, and (c) nifedipine was more potent than diltiazem in inhibiting Ca2+ influx through potential- and receptor-dependent Ca2+ channels. | lld:pubmed |
| pubmed-article:1696655 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1696655 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696655 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1696655 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1696655 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:1696655 | pubmed:author | pubmed-author:MarínJJ | lld:pubmed |
| pubmed-article:1696655 | pubmed:author | pubmed-author:GuerraPP | lld:pubmed |
| pubmed-article:1696655 | pubmed:author | pubmed-author:Fernandez-Alf... | lld:pubmed |
| pubmed-article:1696655 | pubmed:author | pubmed-author:ReviriegoJJ | lld:pubmed |
| pubmed-article:1696655 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1696655 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:1696655 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1696655 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1696655 | pubmed:pagination | 128-38 | lld:pubmed |
| pubmed-article:1696655 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1696655 | pubmed:meshHeading | pubmed-meshheading:1696655-... | lld:pubmed |
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| pubmed-article:1696655 | pubmed:meshHeading | pubmed-meshheading:1696655-... | lld:pubmed |
| pubmed-article:1696655 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1696655 | pubmed:articleTitle | Effects of Ca2+ antagonists nifedipine and diltiazem on isolated human chorionic arteries and veins. | lld:pubmed |
| pubmed-article:1696655 | pubmed:affiliation | Departamento de Farmcología y Terapéutica, Facultad de Medicina, Universidad de Extremadura, Madrid, Spain. | lld:pubmed |
| pubmed-article:1696655 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1696655 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1696655 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1696655 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
