| pubmed-article:16942040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C0242402 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C0026548 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C0599740 | lld:lifeskim |
| pubmed-article:16942040 | lifeskim:mentions | umls-concept:C1120262 | lld:lifeskim |
| pubmed-article:16942040 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16942040 | pubmed:dateCreated | 2006-8-31 | lld:pubmed |
| pubmed-article:16942040 | pubmed:abstractText | Here, we report the synthesis of a designed multi-pharmacophore ligand derived from the linkage of a delta selective peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two methylene spacer. The new compound MCL 450 maintains the same characteristics as those the two reference compounds. MCL 450 represents a useful starting point for the synthesis of other multiple opioid ligands endowed with analgesic properties with low tolerance and dependence. | lld:pubmed |
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| pubmed-article:16942040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16942040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16942040 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16942040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16942040 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16942040 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:BalboniGianfr... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:SalvadoriSeve... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:LazarusLawren... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:PengXuemeiX | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:BidlackJean... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:NeumeyerJohn... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:KnappBrian... | lld:pubmed |
| pubmed-article:16942040 | pubmed:author | pubmed-author:TrapellaClaud... | lld:pubmed |
| pubmed-article:16942040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16942040 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:16942040 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:16942040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16942040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16942040 | pubmed:pagination | 5640-3 | lld:pubmed |
| pubmed-article:16942040 | pubmed:dateRevised | 2011-9-19 | lld:pubmed |
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| pubmed-article:16942040 | pubmed:meshHeading | pubmed-meshheading:16942040... | lld:pubmed |
| pubmed-article:16942040 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16942040 | pubmed:articleTitle | New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. | lld:pubmed |
| pubmed-article:16942040 | pubmed:affiliation | Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA. | lld:pubmed |
| pubmed-article:16942040 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16942040 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16942040 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:16942040 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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