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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2006-8-31
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pubmed:abstractText |
Here, we report the synthesis of a designed multi-pharmacophore ligand derived from the linkage of a delta selective peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two methylene spacer. The new compound MCL 450 maintains the same characteristics as those the two reference compounds. MCL 450 represents a useful starting point for the synthesis of other multiple opioid ligands endowed with analgesic properties with low tolerance and dependence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-10585210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-10633042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-10842167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-11428919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-12843580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-15009527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-15267245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-15279847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-15588089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-15771416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-16220969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-16366592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-16392810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-16442279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-1649297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-2838632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-8529134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-9285927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942040-9301674
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2',6'-dimethyltyrosyl-1,2,3,4-tetrah...,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Morphinans,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydroisoquinolines
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5640-3
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:16942040-Animals,
pubmed-meshheading:16942040-CHO Cells,
pubmed-meshheading:16942040-Cricetinae,
pubmed-meshheading:16942040-Cricetulus,
pubmed-meshheading:16942040-Dipeptides,
pubmed-meshheading:16942040-Ligands,
pubmed-meshheading:16942040-Morphinans,
pubmed-meshheading:16942040-Radioligand Assay,
pubmed-meshheading:16942040-Receptors, Opioid,
pubmed-meshheading:16942040-Receptors, Opioid, delta,
pubmed-meshheading:16942040-Receptors, Opioid, kappa,
pubmed-meshheading:16942040-Receptors, Opioid, mu,
pubmed-meshheading:16942040-Structure-Activity Relationship,
pubmed-meshheading:16942040-Tetrahydroisoquinolines
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pubmed:year |
2006
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pubmed:articleTitle |
New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores.
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pubmed:affiliation |
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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