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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-10-2
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pubmed:abstractText |
Clinical gene therapy trials using standard Ad5-based vectors have thus far demonstrated limited efficacy, most likely due to low expression levels of adenoviral receptors on tumor cells. We sought to analyze adenoviral receptor expression levels on primary head and neck squamous cell carcinoma (HNSCC) cells and to determine whether adenoviral retargeting to the CD46 receptor via the Ad5/35 system would increase therapeutic potential for HNSCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1223-31
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pubmed:meshHeading |
pubmed-meshheading:16941521-Adenoviridae,
pubmed-meshheading:16941521-Animals,
pubmed-meshheading:16941521-Carcinoma, Squamous Cell,
pubmed-meshheading:16941521-Cells, Cultured,
pubmed-meshheading:16941521-Disease Models, Animal,
pubmed-meshheading:16941521-Gene Therapy,
pubmed-meshheading:16941521-Head and Neck Neoplasms,
pubmed-meshheading:16941521-Humans,
pubmed-meshheading:16941521-Male,
pubmed-meshheading:16941521-Mice,
pubmed-meshheading:16941521-Mice, SCID,
pubmed-meshheading:16941521-Receptors, Virus,
pubmed-meshheading:16941521-Transduction, Genetic,
pubmed-meshheading:16941521-Transgenes,
pubmed-meshheading:16941521-Treatment Outcome,
pubmed-meshheading:16941521-Tumor Cells, Cultured,
pubmed-meshheading:16941521-Virus Attachment
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pubmed:year |
2006
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pubmed:articleTitle |
Head and neck cancer cells are efficiently infected by Ad5/35 hybrid virus.
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pubmed:affiliation |
Turku Centre for Biotechnology, Abo Akademi University, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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