Linked Life Data

16938274

Source:http://linkedlifedata.com/resource/pubmed/id/16938274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-10-2
pubmed:abstractText
The ventrobasal complex of the thalamus (VB) participates in the transmission and modulation of noxious information. Recent data suggested that GABA(B) receptors in the VB might be involved in the modulation of neuronal activity in response to chronic noxious input. However, in acute inflammatory pain, the role of GABA(B) receptors in the VB remains unknown. The formalin test of nociception was performed in rats stereotaxically injected in the VB contralateral to the formalin-injected paw, with saline (controls), baclofen (0.5 and 0.875 microg), a specific GABA(B) receptor agonist or CGP35348 (25 microg), a GABA(B) receptor antagonist. Control animals exhibited phase 1 (acute pain) and phase 2 (tonic pain) nociception-related activities as previously described. The higher dose of baclofen induced a significant decrease of all pain-related behaviors in both phases of the test and had no observable effects on the animals' motor function, while the lower dose could not reduce the total pain-related activities. Injection of CGP35348 prior to baclofen reduced the antinociceptive effect caused by baclofen during phase 2 in the paw-jerks and in total pain-related activities. CGP35348 alone had antinociceptive effects in both phases, though less pronounced than baclofen 0.875 microg in the total pain-related activities during phase 2. Data demonstrate that both the blockade and the activation of GABA(B) receptors in the VB of rats induce antinociception in acute and tonic pain. An important role for GABA(B) receptors on the thalamic processing of nociceptive input in the VB is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
1115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-47
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16938274-Acute Disease, pubmed-meshheading:16938274-Analgesics, pubmed-meshheading:16938274-Animals, pubmed-meshheading:16938274-Baclofen, pubmed-meshheading:16938274-Behavior, Animal, pubmed-meshheading:16938274-Chronic Disease, pubmed-meshheading:16938274-Disease Models, Animal, pubmed-meshheading:16938274-GABA Agonists, pubmed-meshheading:16938274-GABA Antagonists, pubmed-meshheading:16938274-GABA-B Receptor Agonists, pubmed-meshheading:16938274-GABA-B Receptor Antagonists, pubmed-meshheading:16938274-Male, pubmed-meshheading:16938274-Neural Inhibition, pubmed-meshheading:16938274-Neurons, pubmed-meshheading:16938274-Organophosphorus Compounds, pubmed-meshheading:16938274-Pain, pubmed-meshheading:16938274-Pain Measurement, pubmed-meshheading:16938274-Pain Threshold, pubmed-meshheading:16938274-Rats, pubmed-meshheading:16938274-Receptors, GABA-B, pubmed-meshheading:16938274-Synaptic Transmission, pubmed-meshheading:16938274-Time Factors, pubmed-meshheading:16938274-Ventral Thalamic Nuclei, pubmed-meshheading:16938274-gamma-Aminobutyric Acid
pubmed:year
2006
pubmed:articleTitle
Inhibition of pain behavior by GABA(B) receptors in the thalamic ventrobasal complex: effect on normal rats subjected to the formalin test of nociception.
pubmed:affiliation
Institute of Histology and Embryology, Faculty of Medicine and IBMC, University of Porto, 4200-319 Porto, Portugal.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't