| pubmed-article:16892069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C0014072 | lld:lifeskim |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:16892069 | lifeskim:mentions | umls-concept:C2243187 | lld:lifeskim |
| pubmed-article:16892069 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:16892069 | pubmed:dateCreated | 2006-8-22 | lld:pubmed |
| pubmed-article:16892069 | pubmed:abstractText | Activation of transcription factor NF-kappaB in the central nervous system (CNS) has been linked to autoimmune demyelinating disease; however, it remains unclear whether its function is protective or pathogenic. Here we show that CNS-restricted ablation of 'upstream' NF-kappaB activators NEMO or IKK2 but not IKK1 ameliorated disease pathology in a mouse model of multiple sclerosis, suggesting that 'canonical' NF-kappaB activation in cells of the CNS has a mainly pathogenic function in autoimmune demyelinating disease. NF-kappaB inhibition prevented the expression of proinflammatory cytokines, chemokines and the adhesion molecule VCAM-1 from CNS-resident cells. Thus, NF-kappaB-dependent gene expression in non-microglial cells of the CNS provides a permissive proinflammatory milieu that is critical for CNS inflammation and tissue damage in autoimmune demyelinating disease. | lld:pubmed |
| pubmed-article:16892069 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16892069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16892069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16892069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16892069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16892069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16892069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16892069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16892069 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16892069 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:LassmannHansH | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:PasparakisMan... | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:Schmidt-Suppr... | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:van LooGeertG | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:HuthMarionM | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:MildnerAlexan... | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:SchmidtHaukeH | lld:pubmed |
| pubmed-article:16892069 | pubmed:author | pubmed-author:PrinzMarco... | lld:pubmed |
| pubmed-article:16892069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16892069 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:16892069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16892069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16892069 | pubmed:pagination | 954-61 | lld:pubmed |
| pubmed-article:16892069 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16892069 | pubmed:meshHeading | pubmed-meshheading:16892069... | lld:pubmed |
| pubmed-article:16892069 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16892069 | pubmed:articleTitle | Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. | lld:pubmed |
| pubmed-article:16892069 | pubmed:affiliation | European Molecular Biology Laboratory Mouse Biology Unit, I-00016 Monterotondo, Italy. | lld:pubmed |
| pubmed-article:16892069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16892069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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