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pubmed:abstractText |
A Brucella suis mutant with a nonpolar deletion in the virB8 gene was attenuated in a macrophage infection model. Complementation with the B. suis VirB8 protein expressed from the virB promoter restored virulence. Expression of TraJ, a VirB8 homologue from plasmid pSB102, did not restore virulence; however, virulence was partially restored by a chimeric protein containing the N terminus of the B. suis VirB8 protein and the C-terminal periplasmic domain of TraJ.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale U431, UFR Médecine, CS83021, Avenue Kennedy, 30908 Nîmes Cedex 02, France.
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