Source:http://linkedlifedata.com/resource/pubmed/id/16860030
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2006-7-24
|
| pubmed:abstractText |
Anemia and renal dysfunction (RD) are frequent complications seen in chronic heart failure (HF). However, the prevalence and interaction of these co-morbidities in a representative population of outpatients with chronic HF is poorly described. In this study, it was sought to determine the association between RD and anemia in patients with HF enrolled in a community-based HF program. Nine hundred fifty-five patients with HF due to left ventricular systolic dysfunction were investigated for the prevalence of anemia and its cause and followed for a median of 531 days. Anemia was defined as hemoglobin < 12.0 g/dl in women and < 13.0 g/dl in men. RD was defined as a calculated glomerular filtration rate of < 60 ml/min. The prevalence of anemia was 32%. Fifty-three percent of patients with and 27% of those without anemia had > or = 1 test suggesting hematinic deficiency. The prevalence of RD was 54%. Forty-one percent of patients with and 22% of patients without RD had anemia, with similar proportions associated with iron deficiency in the presence or absence of RD. Anemia and RD independently predicted a worse outcome, and this effect was additive. In conclusion, in outpatients with chronic HF, anemia and RD are common and co-exist but confer independent prognostic information. A deficiency of conventional hematinic factors may cause about 1/3 of anemia in this clinical setting.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0002-9149
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
98
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
391-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16860030-Aged,
pubmed-meshheading:16860030-Anemia,
pubmed-meshheading:16860030-Chronic Disease,
pubmed-meshheading:16860030-Disease Progression,
pubmed-meshheading:16860030-Female,
pubmed-meshheading:16860030-Ferritins,
pubmed-meshheading:16860030-Follow-Up Studies,
pubmed-meshheading:16860030-Glomerular Filtration Rate,
pubmed-meshheading:16860030-Heart Failure,
pubmed-meshheading:16860030-Hemoglobins,
pubmed-meshheading:16860030-Humans,
pubmed-meshheading:16860030-Male,
pubmed-meshheading:16860030-Myocardial Contraction,
pubmed-meshheading:16860030-Prevalence,
pubmed-meshheading:16860030-Prognosis,
pubmed-meshheading:16860030-Renal Insufficiency,
pubmed-meshheading:16860030-Retrospective Studies,
pubmed-meshheading:16860030-Survival Rate
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Anemia, renal dysfunction, and their interaction in patients with chronic heart failure.
|
| pubmed:affiliation |
Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom. ramesh@desilva84.freeserve.co.uk
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| pubmed:publicationType |
Journal Article,
Comparative Study
|