Linked Life Data

16841954

Source:http://linkedlifedata.com/resource/pubmed/id/16841954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2006-7-17
pubmed:abstractText
Gold nanoparticle (Au-NP) seeds were adsorbed onto the surface of a self-assembled monolayer (SAM)-modified electrode. With the treatment of this modified electrode by Au-NPs growth solution containing different concentrations of H2O2 or cholesterol along with cholesterol oxidase (ChOx), the Au-NP seeds on the electrode surface were enlarged in varying degrees. As a result, the peak currents in corresponding cyclic voltammograms were inversely proportional to the concentration of H2O2 or cholesterol. ChOx was also further modified onto the surface of Au/SAM/Au-NP electrode to prepare Au/SAM/Au-NP/ChOx electrode. Using the enzyme-modified electrode to detect cholesterol, which also utilized the enlargement of the NPs, an extraordinary low detection limit of 5 x 10(-9) M was achieved and two linear dependence ranges of 7.5 x 10(-8)-1 x 10(-6) and 1 x 10(-6)-5 x 10(-5) M were obtained. Consequently, new kinds of H2O2 and cholesterol biosensors could be fabricated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-2700
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5227-30
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Enlargement of gold nanoparticles on the surface of a self-assembled monolayer modified electrode: a mode in biosensor design.
pubmed:affiliation
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't