| pubmed-article:16829576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16829576 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:16829576 | lifeskim:mentions | umls-concept:C0026455 | lld:lifeskim |
| pubmed-article:16829576 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:16829576 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16829576 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:16829576 | pubmed:issue | 29 | lld:pubmed |
| pubmed-article:16829576 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16829576 | pubmed:abstractText | Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. We have previously reported that a novel transcription factor R1 (RAM2/CDCA7L/JPO2) inhibits the MAO A promoter and enzymatic activities. This study reports the roles of MAO A and R1 in apoptosis and proliferation. We have found that in serum starvation-induced apoptosis, p38 kinase, MAO A, and caspase-3 were increased, whereas Bcl-2 and R1 were reduced. Using a p38 kinase inhibitor, R1 overexpression, and MAO A inhibitor, we have shown that MAO A and R1 are downstream of p38 kinase and Bcl-2, but upstream of caspase-3. Inhibition of MAO A prevents cell apoptosis. This notion was further supported by the finding that serum starvation-induced apoptosis is reduced in cortical brain cells from MAO A-deficient mice compared with WT. In addition, we found that MAO A and R1 are involved in the c-Myc-induced proliferative signaling pathway in the presence of serum. Immunoprecipitation and immunohistochemistry experiments indicate that the oncogene c-Myc colocalizes with R1 and induces R1 gene expression. Using R1 overexpression, R1 small interfering RNA, and a MAO A inhibitor, we found that R1 and MAO A act upstream of cyclin D1 and E2F1. In summary, this study demonstrates the functions of MAO A and its repressor R1 in apoptotic signaling pathways. | lld:pubmed |
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| pubmed-article:16829576 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16829576 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16829576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16829576 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16829576 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:16829576 | pubmed:author | pubmed-author:ChenKevinK | lld:pubmed |
| pubmed-article:16829576 | pubmed:author | pubmed-author:OuXiao-MingXM | lld:pubmed |
| pubmed-article:16829576 | pubmed:author | pubmed-author:ShihJean CJC | lld:pubmed |
| pubmed-article:16829576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16829576 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:16829576 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:16829576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16829576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16829576 | pubmed:pagination | 10923-8 | lld:pubmed |
| pubmed-article:16829576 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16829576 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16829576 | pubmed:articleTitle | Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. | lld:pubmed |
| pubmed-article:16829576 | pubmed:affiliation | Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA. | lld:pubmed |
| pubmed-article:16829576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16829576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16829576 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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