Linked Life Data

16795089

Source:http://linkedlifedata.com/resource/pubmed/id/16795089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-10-17
pubmed:abstractText
The impact of endocrine-disrupting chemicals (EDCs) on human health is not yet clear because of difficulties in ascertaining their biological effects. In the present study, we evaluated exposure to the EDC, bisphenol A (BPA), in 172 Koreans in relation to biomarkers of susceptibility and effect. The subjects completed questionnaires, which documented occupation, education, lifestyle factors, potential sources of BPA-exposure, and the occurrence of self-diagnosed endocrine disorders. None of the subjects were occupationally exposed to BPA; however, urinary levels of conjugated BPA, determined by HPLC/FD, ranged from 0.03-62.4 microg/l (median, 7.86). The frequencies of potential susceptibility biomarkers, the UGT1A6-Arg184Ser and the SULT1A1-Arg213His polymorphisms, were not associated with urinary BPA levels, either as single genes or in combination. Indirect effects of BPA exposure on the susceptibility to mutagens were evaluated by comparing urinary BPA concentrations with MNNG-induced sister-chromatid exchange (SCE) in lymphocytes cultured from the subjects. BPA exposure showed marginal or significant associations with theSCEs induced by the low doses of MNNG (0-0.4 mM). However, there was no overall association between urinary BPA levels and MNNG-induced frequency at doses ranging from 0.2-0.6 mM. Finally, we did not detect an association between urinary BPA concentration and endocrine-related disorders. Even though we were unable to find a strong association between BPA exposure and a biological response, possibly because of the limited number of subjects, we observed that most of the subjects were exposed to BPA. Therefore, continuous biological monitoring of BPA is a prudent measure to prevent possible BPA-related health risks.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0893-6692
pubmed:author
pubmed:copyrightInfo
(c) 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
571-8
pubmed:dateRevised
2011-5-19
pubmed:meshHeading
pubmed-meshheading:16795089-Adult, pubmed-meshheading:16795089-Arylsulfotransferase, pubmed-meshheading:16795089-Biological Markers, pubmed-meshheading:16795089-Blood Cells, pubmed-meshheading:16795089-Cells, Cultured, pubmed-meshheading:16795089-Endocrine Disruptors, pubmed-meshheading:16795089-Endocrine System Diseases, pubmed-meshheading:16795089-Environmental Exposure, pubmed-meshheading:16795089-Female, pubmed-meshheading:16795089-Genetic Predisposition to Disease, pubmed-meshheading:16795089-Glucuronosyltransferase, pubmed-meshheading:16795089-Humans, pubmed-meshheading:16795089-Male, pubmed-meshheading:16795089-Methylnitronitrosoguanidine, pubmed-meshheading:16795089-Middle Aged, pubmed-meshheading:16795089-Phenols, pubmed-meshheading:16795089-Polymorphism, Genetic, pubmed-meshheading:16795089-Sister Chromatid Exchange, pubmed-meshheading:16795089-Sulfotransferases
pubmed:year
2006
pubmed:articleTitle
Urinary concentrations of bisphenol A in relation to biomarkers of sensitivity and effect and endocrine-related health effects.
pubmed:affiliation
Department of Toxicology, College of Pharmacy, Sookmyung Women's University, Yongsan-Gu, Seoul 140-742, Republic of Korea. myang@sookmyung.ac.kr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't