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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8766
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pubmed:dateCreated |
1991-9-24
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pubmed:abstractText |
To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 micrograms/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
338
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-2
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1678803-Adult,
pubmed-meshheading:1678803-Aged,
pubmed-meshheading:1678803-Autoantibodies,
pubmed-meshheading:1678803-Autoimmune Diseases,
pubmed-meshheading:1678803-Autoimmunity,
pubmed-meshheading:1678803-Breast Neoplasms,
pubmed-meshheading:1678803-Drug Administration Schedule,
pubmed-meshheading:1678803-Female,
pubmed-meshheading:1678803-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:1678803-Humans,
pubmed-meshheading:1678803-Hypothyroidism,
pubmed-meshheading:1678803-Male,
pubmed-meshheading:1678803-Middle Aged,
pubmed-meshheading:1678803-Sarcoma,
pubmed-meshheading:1678803-Soft Tissue Neoplasms,
pubmed-meshheading:1678803-Thyroid Hormones,
pubmed-meshheading:1678803-Thyroiditis
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pubmed:year |
1991
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pubmed:articleTitle |
Reversible thyroid dysfunction during treatment with GM-CSF.
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pubmed:affiliation |
Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article
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