Source:http://linkedlifedata.com/resource/pubmed/id/16784491
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-6-20
|
| pubmed:abstractText |
The majority of thymocytes die in the thymus, whereas small populations of T cells that are able to specifically recognize an antigen are considered to survive. Although the thymic selection is thought to have a profound effect on T-cell receptor (TCR) repertoire, little is known how TCR repertoire is formed during the thymocyte developmental process. We examined TCRalpha- and beta-chain variable regions (TCRAV and TCRBV) repertoire in thymic T-cell subpopulations from mice bearing different major histocompatibility (MHC) haplotypes. In Balb/c mice, but not C57BL/6, remarkable alterations of the TCR repertoire were observed in mature T-cell subpopulations as previously reported. In contrast, there were no significant differences of TCRBV repertoire between DN3 (CD25(+)CD44(-)) and DN4 (CD25(-)CD44(-)), and between DN4 and DP. These results suggest that (1) TCR repertoire of mature T cells was formed mainly under the influence of endogenous superantigens, while MHC haplotypes played the least role; (2) the 'beta-selection' process during immature stages had little impact on TCRBV repertoire formation; and (3) TCR repertoire in immature T-cell subpopulations was extremely similar between different strains of mice. We thus consider that pre-selection TCR repertoire in immature T cells could be determined by some genetic factors conserved among different strains.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0300-9475
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
53-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16784491-Animals,
pubmed-meshheading:16784491-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16784491-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16784491-Cell Differentiation,
pubmed-meshheading:16784491-Clonal Deletion,
pubmed-meshheading:16784491-Female,
pubmed-meshheading:16784491-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:16784491-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:16784491-Male,
pubmed-meshheading:16784491-Mammary Tumor Virus, Mouse,
pubmed-meshheading:16784491-Mice,
pubmed-meshheading:16784491-Mice, Inbred BALB C,
pubmed-meshheading:16784491-Mice, Inbred C57BL,
pubmed-meshheading:16784491-Polymerase Chain Reaction,
pubmed-meshheading:16784491-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:16784491-Species Specificity,
pubmed-meshheading:16784491-Spleen,
pubmed-meshheading:16784491-T-Lymphocyte Subsets,
pubmed-meshheading:16784491-Thymus Gland
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Alteration of T-cell receptor repertoires during thymic T-cell development.
|
| pubmed:affiliation |
Division of Immunology and Embryology, Department of Cell Biology, Tohoku University School of Medicine, Sendai, Japan. matsu@immem.med.tohoku.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|