Linked Life Data

16768298

Source:http://linkedlifedata.com/resource/pubmed/id/16768298

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-6-13
pubmed:abstractText
Cancer prevalence is the proportion of people in a population diagnosed with cancer in the past and still alive. One way to estimate prevalence is via population-based registries, where data on diagnosis and life status of all incidence cases occurring in the covered population are collected. In this paper, a method to estimate the complete prevalence and its variance from population-based registries is presented. In order to obtain unbiased estimates of the complete prevalence, its calculation can be thought as made by three steps. Step 1 counts the incidence cases diagnosed during the period of registration and still alive. Step 2 estimates the expected number of survivors among cases lost to follow-up. Step 3 estimates the complete prevalence by taking into account cases diagnosed before the start of registration. The combination of steps 1+2 is defined as the counting method, to estimate the limited duration prevalence; step 3 is the completeness index method, to estimate the complete prevalence. For early established registries, steps 1+2 are more important than step 3, because observation time is long enough to include all past diagnosed cases still alive in the prevalence data. For more recently established registries, step 3 is by far the most critical because a large part of prevalence might have been diagnosed before the period of registration (Corazziari I, Mariotto A, Capocaccia R. Correcting the completeness bias of observed prevalence. Tumori 1999; 85: 370-81). The work by Clegg LX, Gail MH, Feuer EJ. Estimating the variance of disease-prevalence estimates from population-based registries. Biometrics 2002; 55: 1137-44. considers the problem of the variability of the estimated prevalence up to step 2. To our knowledge, no other work has considered the variability induced by correcting for the unobserved cases diagnosed before the period of registration, crucial to estimate the prevalence in recent registries. An analytic approach is considered to calculate the variance of step 3. A unified expression for the variance of the prevalence allowing for steps 1 through 3 is obtained. Some applications to cancer data are presented.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0962-2802
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Estimating the variance of cancer prevalence from population-based registries.
pubmed:affiliation
Istituto di Ricerche sulla Popolazione e le Politiche Sociali, Consiglio Nazionale delle Ricerche, Roma, Italy. a.gigli@irpps.cnr.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural