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rdf:type |
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lifeskim:mentions |
umls-concept:C0037083,
umls-concept:C0078058,
umls-concept:C0086597,
umls-concept:C0205144,
umls-concept:C0208973,
umls-concept:C0302600,
umls-concept:C0337611,
umls-concept:C1256770,
umls-concept:C1416471,
umls-concept:C1510802,
umls-concept:C1517892,
umls-concept:C1704666,
umls-concept:C1710082
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-18
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pubmed:abstractText |
Vascular endothelial growth factor (VEGF) induces angiogenesis by stimulating reactive oxygen species (ROS) production primarily through the VEGF receptor-2 (VEGFR2). One of the initial responses in established vessels to stimulate angiogenesis is loss of vascular endothelial (VE)-cadherin-based cell-cell adhesions; however, little is known about the underlying mechanisms. IQGAP1 is a novel VEGFR2 binding protein, and it interacts directly with actin, cadherin, and beta-catenin, thereby regulating cell motility and morphogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/IQ motif containing GTPase...,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1991-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16763158-Adherens Junctions,
pubmed-meshheading:16763158-Animals,
pubmed-meshheading:16763158-Antigens, CD,
pubmed-meshheading:16763158-Cadherins,
pubmed-meshheading:16763158-Cell Communication,
pubmed-meshheading:16763158-Cells, Cultured,
pubmed-meshheading:16763158-Hindlimb,
pubmed-meshheading:16763158-Humans,
pubmed-meshheading:16763158-Ischemia,
pubmed-meshheading:16763158-Mice,
pubmed-meshheading:16763158-Neovascularization, Physiologic,
pubmed-meshheading:16763158-Phosphorylation,
pubmed-meshheading:16763158-Reactive Oxygen Species,
pubmed-meshheading:16763158-Signal Transduction,
pubmed-meshheading:16763158-Subcellular Fractions,
pubmed-meshheading:16763158-Tissue Distribution,
pubmed-meshheading:16763158-Tyrosine,
pubmed-meshheading:16763158-Vascular Endothelial Growth Factor A,
pubmed-meshheading:16763158-Vascular Endothelial Growth Factor Receptor-2,
pubmed-meshheading:16763158-beta Catenin,
pubmed-meshheading:16763158-ras GTPase-Activating Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis.
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pubmed:affiliation |
Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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