| pubmed-article:16751178 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16751178 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:16751178 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16751178 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16751178 | lifeskim:mentions | umls-concept:C1518904 | lld:lifeskim |
| pubmed-article:16751178 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:16751178 | pubmed:dateCreated | 2006-6-5 | lld:pubmed |
| pubmed-article:16751178 | pubmed:abstractText | The Wnt signaling pathway controls cell proliferation and body patterning throughout development. A surprising number of cytoplasmic Wnt regulators (e.g., beta-catenin, Bcl-9/Lgs, APC, Axin) also appear, often transiently, in the nucleus. beta-Catenin is an integral component of E-cadherin complexes at intercellular adherens junctions, but also recruits chromatin remodeling complexes to activate transcription in the nucleus. The APC tumor suppressor is a part of the cytoplasmic beta-catenin destruction complex, yet also counteracts beta-catenin transactivation and histone H3K4 methylation at Wnt target genes. Furthermore, APC coordinates the cyclic exchange of Wnt coregulator complexes at the DNA. These opposing roles of APC and beta-catenin enable a rapid coordination of gene expression and cytoskeletal organization throughout the cell in response to signaling. | lld:pubmed |
| pubmed-article:16751178 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16751178 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751178 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16751178 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16751178 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16751178 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16751178 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:16751178 | pubmed:author | pubmed-author:JonesKatherin... | lld:pubmed |
| pubmed-article:16751178 | pubmed:author | pubmed-author:WillertKarlK | lld:pubmed |
| pubmed-article:16751178 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16751178 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16751178 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:16751178 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16751178 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16751178 | pubmed:pagination | 1394-404 | lld:pubmed |
| pubmed-article:16751178 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:meshHeading | pubmed-meshheading:16751178... | lld:pubmed |
| pubmed-article:16751178 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16751178 | pubmed:articleTitle | Wnt signaling: is the party in the nucleus? | lld:pubmed |
| pubmed-article:16751178 | pubmed:affiliation | Department of Molecular and Cellular Medicine, University of California, San Diego, La Jolla, California 92093, USA. | lld:pubmed |
| pubmed-article:16751178 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16751178 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16751178 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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