Linked Life Data

16750814

Source:http://linkedlifedata.com/resource/pubmed/id/16750814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-6-19
pubmed:databankReference
pubmed:abstractText
Caveolin-3 is the muscle-specific form of the caveolin protein family and plays an important role in modulating both the morphological appearance and function of caveolae. In this study, we cloned and characterized caveolin-3 from porcine muscle. The promoter of porcine caveolin-3 contained three consensus E box elements and one RORalpha2 monomeric binding motif. The deduced amino acid sequence of porcine caveolin-3 contains a WW domain. This gene was mapped to SSC13 q23-q24 by the SCHP and the IMpRH panel. RT-PCR analyses showed that caveolin-3 was expressed specifically in skeletal muscle and heart. And we provide the first evidence that caveolin-3 has a certain regulated expression pattern during the prenatal period of the porcine skeletal muscle development. This result suggests that the caveolin-3 gene might be a candidate gene of meat production trait and provides some information for establishing of an animal model using pig to study human caveolinopathies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
346
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Molecular characterization and expression analysis of the porcine caveolin-3 gene.
pubmed:affiliation
Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't