pubmed-article:1674014 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C0025219 | lld:lifeskim |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C0393770 | lld:lifeskim |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:1674014 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:1674014 | pubmed:issue | 8750 | lld:pubmed |
pubmed-article:1674014 | pubmed:dateCreated | 1991-6-11 | lld:pubmed |
pubmed-article:1674014 | pubmed:abstractText | The actions of melatonin on the sleep-wake cycle were investigated by means of a randomised, double-blind, placebo-controlled trial in 8 subjects with a delayed sleep phase syndrome attending a sleep disorders clinic. In randomised order the subjects received placebo or melatonin 5 mg daily for 4 weeks with a 1 week washout period between the treatments. Drug or placebo was given at 2200 h, 5 h before the mean time of sleep onset determined by pretrial sleep logs. In all 8 subjects sleep onset time (mean advance 82 [range 19-124] min; p less than 0.01) and wake time (117 [10-187] min; p less than 0.01) were significantly earlier during melatonin treatment than during placebo. Mean total sleep time was slightly less on melatonin (8 h 12 min) than on placebo (8 h 46 min). Alertness acrophase calculated from the subjects' ratings of alertness made every 2 h while awake was unaltered. Melatonin may act as a phase-setter for sleep-wake cycles in subjects with a delayed sleep phase syndrome. | lld:pubmed |
pubmed-article:1674014 | pubmed:language | eng | lld:pubmed |
pubmed-article:1674014 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1674014 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:1674014 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1674014 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1674014 | pubmed:month | May | lld:pubmed |
pubmed-article:1674014 | pubmed:issn | 0140-6736 | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:EnglishJJ | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:ParkesJ DJD | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:ArendtJJ | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:VignauJJ | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:AlvarezBB | lld:pubmed |
pubmed-article:1674014 | pubmed:author | pubmed-author:DahlitzMM | lld:pubmed |
pubmed-article:1674014 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1674014 | pubmed:day | 11 | lld:pubmed |
pubmed-article:1674014 | pubmed:volume | 337 | lld:pubmed |
pubmed-article:1674014 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1674014 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1674014 | pubmed:pagination | 1121-4 | lld:pubmed |
pubmed-article:1674014 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:1674014 | pubmed:year | 1991 | lld:pubmed |
pubmed-article:1674014 | pubmed:articleTitle | Delayed sleep phase syndrome response to melatonin. | lld:pubmed |
pubmed-article:1674014 | pubmed:affiliation | Department of Neurology, King's College School of Medicine and Dentistry, University of London, UK. | lld:pubmed |
pubmed-article:1674014 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1674014 | pubmed:publicationType | Clinical Trial | lld:pubmed |
pubmed-article:1674014 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
pubmed-article:1674014 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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