Linked Life Data

16733820

Source:http://linkedlifedata.com/resource/pubmed/id/16733820

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pubmed-article:16733820pubmed:abstractTextNatural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate presents nociceptive actions, in this study it was investigated the effects of hydroalcooholic extracts from Drymis winteri (polygodial and drimanial) on the glutamatergic system in rat brain. Polygodial and drimanial inhibited glutamate uptake by astrocytes, as well as by cortical, hippocampal and striatal slices, and increased synaptosomal glutamate release. These concurrent effects would predispose to an increase in the extracellular glutamate concentrations, leading to possible neurotoxic effects (excitotoxicity) of these natural compounds, which would suggest the need for some caution in their therapeutic application.lld:pubmed
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pubmed-article:16733820pubmed:authorpubmed-author:SouzaDiogo...lld:pubmed
pubmed-article:16733820pubmed:authorpubmed-author:YunesRosendo...lld:pubmed
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pubmed-article:16733820pubmed:volume31lld:pubmed
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pubmed-article:16733820pubmed:pagination431-8lld:pubmed
pubmed-article:16733820pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:16733820pubmed:year2006lld:pubmed
pubmed-article:16733820pubmed:articleTitleThe sesquiterpenes polygodial and drimanial in vitro affect glutamatergic transport in rat brain.lld:pubmed
pubmed-article:16733820pubmed:affiliationDepartamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, 90035-003, Porto Alegre, RS, Brazil.lld:pubmed
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