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pubmed-article:16729780pubmed:abstractTextThe central role of chronic inflammation of the airways in asthma pathogenesis is supported by the efficacy of corticosteroids in controlling clinical symptoms. However, the search continues for potentially safer anti-inflammatory alternatives. Roflumilast is an oral, once-daily phosphodiesterase type 4 inhibitor with anti-inflammatory activity in preclinical models of asthma and chronic obstructive pulmonary disease.lld:pubmed
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pubmed-article:16729780pubmed:articleTitleEfficacy and safety of roflumilast in the treatment of asthma.lld:pubmed
pubmed-article:16729780pubmed:affiliationDivision of Pulmonology, Department of Medicine, University of Cape Town, South Africa. ebateman@uctgsh1.uct.ac.zalld:pubmed
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