Linked Life Data

16715205

Source:http://linkedlifedata.com/resource/pubmed/id/16715205

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pubmed-article:16715205pubmed:abstractTextIn idiopathic Parkinson's disease (PD), a tremor-dominant type (TDT), an akinetic-rigid type (ART), and a mixed type (MT) are distinguished. We compared cerebral [I-123]FP-CIT SPECT in the PD subtypes (67 patients Hoehn and Yahr stage 1:26 with ART, 19 with MT, 22 with TDT). We measured the ratios putamen/occipital lobe binding and caudate nucleus/occipital lobe binding. Parkinsonian motor symptoms were quantified by UPDRS motor scale. In both putamen and caudate nucleus contralateral to the clinically affected body side TDT patients showed a significantly higher FP-CIT uptake than ART or MT patients (ANOVA; p<0.01). Contralateral putamen and caudate nucleus FP-CIT uptake correlated significantly with severity of rigidity (p<0.01) and hypokinesia (p<0.01) but not with severity of resting or postural tremor (p>0.05). The missing correlation between striatal FP-CIT uptake and tremor suggests, that further systems besides the nigrostriatal dopaminergic system may contribute to generation of parkinsonian tremor.lld:pubmed
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pubmed-article:16715205pubmed:articleTitleStriatal FP-CIT uptake differs in the subtypes of early Parkinson's disease.lld:pubmed
pubmed-article:16715205pubmed:affiliationDepartment of Neurology, Saarland University, Homburg/Saar, Germany.lld:pubmed
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