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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-5-18
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pubmed:databankReference |
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pubmed:abstractText |
We report the first isolation and characterization of the canine NKX2-5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2-5 across a number of different species. Given the critical role of NKX2-5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2-5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0931-2668
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-6
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pubmed:meshHeading |
pubmed-meshheading:16706928-Amino Acid Sequence,
pubmed-meshheading:16706928-Animals,
pubmed-meshheading:16706928-Base Sequence,
pubmed-meshheading:16706928-DNA Primers,
pubmed-meshheading:16706928-Dogs,
pubmed-meshheading:16706928-Female,
pubmed-meshheading:16706928-Gene Order,
pubmed-meshheading:16706928-Genes, Homeobox,
pubmed-meshheading:16706928-Homeodomain Proteins,
pubmed-meshheading:16706928-Molecular Sequence Data,
pubmed-meshheading:16706928-Mutation,
pubmed-meshheading:16706928-Polymerase Chain Reaction,
pubmed-meshheading:16706928-Sequence Alignment,
pubmed-meshheading:16706928-Sequence Homology, Amino Acid,
pubmed-meshheading:16706928-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Isolation and characterization of the canine NKX2-5 gene.
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pubmed:affiliation |
Section of Internal Medicine, School of Veterinary Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea. hyun5188@kangwon.ac.kr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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