| pubmed-article:16682775 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C1427952 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0010423 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0033629 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:16682775 | lifeskim:mentions | umls-concept:C0439611 | lld:lifeskim |
| pubmed-article:16682775 | pubmed:issue | Pt 5 | lld:pubmed |
| pubmed-article:16682775 | pubmed:dateCreated | 2006-5-9 | lld:pubmed |
| pubmed-article:16682775 | pubmed:abstractText | The large subunit of the essential pre-mRNA splicing factor U2 auxiliary factor (U2AF65) binds the polypyrimidine tract near the 3' splice site of pre-mRNA introns and directs the association of the U2 small nuclear ribonucleoprotein particle (U2 snRNP) of the spliceosome with the pre-mRNA. Protein engineering, in which the flexible linker region connecting tandem RNA-recognition motifs (RRMs) within the U2AF65 RNA-binding domain was partially deleted, allowed successful crystallization of the protein-nucleic acid complex. Cocrystals of a U2AF65 variant with a deoxyuridine dodecamer diffract X-rays to 2.9 angstroms resolution and contain one complex per asymmetric unit. | lld:pubmed |
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| pubmed-article:16682775 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16682775 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16682775 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16682775 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16682775 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16682775 | pubmed:month | May | lld:pubmed |
| pubmed-article:16682775 | pubmed:issn | 1744-3091 | lld:pubmed |
| pubmed-article:16682775 | pubmed:author | pubmed-author:SickmierE... | lld:pubmed |
| pubmed-article:16682775 | pubmed:author | pubmed-author:KielkopfClara... | lld:pubmed |
| pubmed-article:16682775 | pubmed:author | pubmed-author:FratoKatherin... | lld:pubmed |
| pubmed-article:16682775 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16682775 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16682775 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:16682775 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16682775 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16682775 | pubmed:pagination | 457-9 | lld:pubmed |
| pubmed-article:16682775 | pubmed:dateRevised | 2011-5-5 | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:meshHeading | pubmed-meshheading:16682775... | lld:pubmed |
| pubmed-article:16682775 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16682775 | pubmed:articleTitle | Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering. | lld:pubmed |
| pubmed-article:16682775 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. | lld:pubmed |
| pubmed-article:16682775 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16682775 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:11338 | entrezgene:pubmed | pubmed-article:16682775 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16682775 | lld:entrezgene |
