| pubmed-article:1668113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0235480 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0071234 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0032172 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0279389 | lld:lifeskim |
| pubmed-article:1668113 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:1668113 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1668113 | pubmed:dateCreated | 1992-7-30 | lld:pubmed |
| pubmed-article:1668113 | pubmed:abstractText | Nine simple and structurally flexible PAF antagonists were synthesized and their inhibitory effects on PAF induced platelet aggregation were measured. Compounds with PAF antagonistic activity exhibited a negative electrostatic potential generated by two trimethoxyphenyl groups (isocontour at -10 Kcal/mole) at various distances between the negative clouds. The optimal distance between the atoms generating the "cache-oreilles" system for exhibiting potent PAF antagonistic activity is estimated to be 11-13 A. In the flexible molecules studied, the dispersion of the electronic distribution is not necessarily favorable for anti-PAF activity. The data support the simple bipolarized model for the PAF receptor that has been proposed by the authors. | lld:pubmed |
| pubmed-article:1668113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1668113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1668113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1668113 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1668113 | pubmed:issn | 0024-4201 | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:FryeG DGD | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:GodfroidJ JJJ | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:BraquetPP | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:HeymansFF | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:HosfordDD | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:RedeuilhCC | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:BattJ PJP | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:Lamotte-Brass... | lld:pubmed |
| pubmed-article:1668113 | pubmed:author | pubmed-author:LamouriAA | lld:pubmed |
| pubmed-article:1668113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1668113 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:1668113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1668113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1668113 | pubmed:pagination | 1167-71 | lld:pubmed |
| pubmed-article:1668113 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:meshHeading | pubmed-meshheading:1668113-... | lld:pubmed |
| pubmed-article:1668113 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1668113 | pubmed:articleTitle | PAF receptor and "Cache-oreilles" effect. Simple PAF antagonists. | lld:pubmed |
| pubmed-article:1668113 | pubmed:affiliation | Centre d'Ingéniérie des Protéines, Institut de Chimie, Liége-Sart-Tilman, Belgium. | lld:pubmed |
| pubmed-article:1668113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1668113 | pubmed:publicationType | Comparative Study | lld:pubmed |
