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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-13
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pubmed:abstractText |
The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
292-3
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1665729-Animals,
pubmed-meshheading:1665729-Biphenyl Compounds,
pubmed-meshheading:1665729-Cattle,
pubmed-meshheading:1665729-Cricetinae,
pubmed-meshheading:1665729-Gerbillinae,
pubmed-meshheading:1665729-Guinea Pigs,
pubmed-meshheading:1665729-Humans,
pubmed-meshheading:1665729-Male,
pubmed-meshheading:1665729-Mice,
pubmed-meshheading:1665729-Muscle, Smooth,
pubmed-meshheading:1665729-Muscle, Smooth, Vascular,
pubmed-meshheading:1665729-Rabbits,
pubmed-meshheading:1665729-Radioligand Assay,
pubmed-meshheading:1665729-Rats,
pubmed-meshheading:1665729-Receptors, Neurotransmitter,
pubmed-meshheading:1665729-Receptors, Tachykinin,
pubmed-meshheading:1665729-Species Specificity,
pubmed-meshheading:1665729-Spinal Cord,
pubmed-meshheading:1665729-Tachykinins
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pubmed:year |
1991
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pubmed:articleTitle |
Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.
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pubmed:affiliation |
Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire.
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pubmed:publicationType |
Journal Article,
In Vitro
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