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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1992-2-18
|
| pubmed:abstractText |
The aim of this study was to estimate bone-marrow blood flow (BMBF) in man and to correlate this with myelosuppression induced by cytostatic treatment dosed as a function of surface area. Twenty-four patients suffering from small-cell lung cancer participated in the study. Blood flow was measured with the xenon-133 washout technique. The 133Xe clearance measurement took place in conjunction with the pre-treatment bone-marrow staging procedure (ad modern Radner). Tissue samples were taken for microscopy and for the determination of the blood-to-tissue partition coefficient lambda. After the bone-marrow aspiration, 0.1-0.2 ml of 133Xe in saline was injected into the bone marrow and the cannula was removed. Following a hyperaemic phase of 12 min (7-16 min), monoexponential washouts were demonstrated. The median washout rate constant was 0.0063 min-1 (0.0038-0.0098 min-1). Lambda values of 0.3-3.5 ml g were found, but microscopy of the bone marrow showed a fairly large admixture of peripheral blood. Therefore, the lambda values should be taken with caution and absolute blood-flow values were not calculated. The results demonstrated no correlation between 133Xe clearance from crista iliaca and leucocyte or platelet suppression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0036-5513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
559-63
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1662828-Aged,
pubmed-meshheading:1662828-Antineoplastic Agents,
pubmed-meshheading:1662828-Bone Marrow,
pubmed-meshheading:1662828-Carcinoma, Small Cell,
pubmed-meshheading:1662828-Female,
pubmed-meshheading:1662828-Humans,
pubmed-meshheading:1662828-Leukocyte Count,
pubmed-meshheading:1662828-Lung Neoplasms,
pubmed-meshheading:1662828-Male,
pubmed-meshheading:1662828-Middle Aged,
pubmed-meshheading:1662828-Platelet Count,
pubmed-meshheading:1662828-Regional Blood Flow,
pubmed-meshheading:1662828-Regression Analysis,
pubmed-meshheading:1662828-Xenon Radioisotopes
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Clearance of xenon-133 from bone marrow in patients with small-cell lung cancer.
|
| pubmed:affiliation |
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Denmark.
|
| pubmed:publicationType |
Journal Article
|