Linked Life Data

16627924

Source:http://linkedlifedata.com/resource/pubmed/id/16627924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-4-21
pubmed:abstractText
A trail of evidence has led to an unexpected intersection of topical issues in condensed matter physics and cytoskeletal biology. On the one hand, the glass transition and the jammed state are two outstanding unsolved problems; such systems are out-of-equilibrium, disordered, and their transitions between solid-like and liquid-like states are not understood. On the other hand, cellular systems are increasingly being considered as interconnected maps of protein interactions that are highly specific and tightly regulated but, even when such comprehensive maps become available, they may be insufficient to define biological function at the integrative level because they do not encompass principles that govern dynamics at intermediate (meso) scales of organization. It is interesting, therefore, that the cytoskeleton of the living cell shows physical properties and remodeling dynamics with all the same signatures as soft inert condensed systems, although with important differences as well. Data reviewed here suggest that trapping, intermittency, and approach to kinetic arrest represent mesoscale features of collective protein-protein interactions linking underlying molecular events to integrative cellular functions such as crawling, contraction and remodeling. Because these are crucial cell functions, this synthesis may offer new perspectives on a variety of disorders including infectious disease, cardiovascular disease, asthma and cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0006-355X
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-30
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Deformability, dynamics, and remodeling of cytoskeleton of the adherent living cell.
pubmed:affiliation
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. glenorma@hsph.harvard.edu
pubmed:publicationType
Journal Article, Review