Linked Life Data

16619617

Source:http://linkedlifedata.com/resource/pubmed/id/16619617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-4-19
pubmed:abstractText
Xanthurenic acid (XA) has been implicated as an inducer in vivo of exflagellation in Plasmodium spp. Consequently, the development of Plasmodium gallinaceum was assessed in a white-eye mosquito strain, kh(w), of Aedes aegypti (L.), which is deficient in XA because of a mutation of the gene encoding the enzyme kynurenine hydroxylase, and in a transformed line of kh(w) mosquitoes that carry the wild-type cn+ gene of Drosophila melanogaster Meigen and express a functional enzyme necessary for XA production. Although XA was not detectable in kh(w) mosquitoes by using high-pressure liquid chromatography with electrochemical detection, parasites were able to develop. Transformed kh(w) mosquitoes failed to consistently support parasite development at higher prevalences and mean intensities than did the nontransformed kh(w) lines, even though XA was detectable. These data suggest that factors other than XA may play a role in initiating Plasmodium development in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2585
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-22
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Plasmodium development in white-eye (kh(w)) and transformed strains (kh43) of Aedes aegypti (Diptera: Culicidae).
pubmed:affiliation
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural