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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-14
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pubmed:abstractText |
Evidence suggests that CD4+CD25+ regulatory T cells play a crucial role in the suppression of intestinal inflammation. However, their role in the suppression of inflammatory bowel disease has not yet been addressed. We examined the proportion of regulatory T cells in inflammatory bowel disease. First, we isolated CD4+CD45RO+CD25+ T cells from the peripheral blood of healthy persons and showed that these cells suppressed T cell proliferation profoundly and expressed FoxP3 abundantly, revealing that they are regulatory cells. Then the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry. CD4+CD45RO+CD25+ T cell frequency was significantly lower in active ulcerative colitis than in the control and inactive ulcerative colitis. CD4+CD45RO+CD25+ T cell frequency was inversely correlated with the clinical and endoscopic severity of ulcerative colitis. These results suggest that a deficiency of regulatory T cells is associated with the progression of ulcerative colitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0163-2116
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
677-86
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16614988-Adolescent,
pubmed-meshheading:16614988-Adult,
pubmed-meshheading:16614988-Antigens, CD45,
pubmed-meshheading:16614988-Base Sequence,
pubmed-meshheading:16614988-Biological Markers,
pubmed-meshheading:16614988-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16614988-Case-Control Studies,
pubmed-meshheading:16614988-Cells, Cultured,
pubmed-meshheading:16614988-Colitis, Ulcerative,
pubmed-meshheading:16614988-Disease Progression,
pubmed-meshheading:16614988-Female,
pubmed-meshheading:16614988-Humans,
pubmed-meshheading:16614988-Male,
pubmed-meshheading:16614988-Middle Aged,
pubmed-meshheading:16614988-Molecular Sequence Data,
pubmed-meshheading:16614988-Probability,
pubmed-meshheading:16614988-Receptors, Interleukin-2,
pubmed-meshheading:16614988-Reference Values,
pubmed-meshheading:16614988-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16614988-Sensitivity and Specificity,
pubmed-meshheading:16614988-Severity of Illness Index,
pubmed-meshheading:16614988-T-Lymphocytes, Regulatory
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pubmed:year |
2006
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pubmed:articleTitle |
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.
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pubmed:affiliation |
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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