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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-12
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pubmed:abstractText |
We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1530-6984
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
669-76
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16608262-Animals,
pubmed-meshheading:16608262-Cell Line, Tumor,
pubmed-meshheading:16608262-Coated Materials, Biocompatible,
pubmed-meshheading:16608262-Glioblastoma,
pubmed-meshheading:16608262-Humans,
pubmed-meshheading:16608262-Mice,
pubmed-meshheading:16608262-Mice, Nude,
pubmed-meshheading:16608262-Microscopy, Fluorescence,
pubmed-meshheading:16608262-Neovascularization, Pathologic,
pubmed-meshheading:16608262-Oligopeptides,
pubmed-meshheading:16608262-Particle Size,
pubmed-meshheading:16608262-Quantum Dots,
pubmed-meshheading:16608262-Spectrophotometry, Infrared,
pubmed-meshheading:16608262-Whole Body Imaging
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pubmed:year |
2006
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|
pubmed:articleTitle |
Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.
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pubmed:affiliation |
Molecular Imaging Program (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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