| pubmed-article:16564638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16564638 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:16564638 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:16564638 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:16564638 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16564638 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16564638 | pubmed:dateCreated | 2006-5-5 | lld:pubmed |
| pubmed-article:16564638 | pubmed:abstractText | Leptin, an adipocyte-derived hormone, reduces food intake by regulating orexigenic and anorexigenic factors in the hypothalamus. Although brain-derived neurotrophic factor is an important anorexigenic factor in the hypothalamus, little is known about the regulation of brain-derived neurotrophic factor expression by leptin in the hypothalamus. In the present study, we examined the effect of leptin on the expression of brain-derived neurotrophic factor in the hypothalamus. I.V. administration of leptin (10 microg/g) led to the increase in the expression of brain-derived neurotrophic factor mRNA, which was observed in the dorsomedial part of the ventromedial hypothalamic nucleus. The increased expression of brain-derived neurotrophic factor mRNA was detected in phosphorylated signal transducer and activator of transcription 3-positive neurons, suggesting that leptin induced brain-derived neurotrophic factor expression in neurons of the dorsomedial part of the ventromedial hypothalamic nucleus. In addition, the expression of brain-derived neurotrophic factor was increased at the protein level in the ventromedial hypothalamic nucleus of leptin-injected mice. Interestingly, brain-derived neurotrophic factor-positive fibers also increased in the ventromedial hypothalamic nucleus and dorsomedial hypothalamic nucleus of leptin-injected mice, which were in close apposition to tyrosine kinase receptor B-immunoreactive neurons and colocalized with synaptophysin, a marker of presynaptic terminals. These results suggest that leptin induces brain-derived neurotrophic factor expression in the dorsomedial part of the ventromedial hypothalamic nucleus and brain-derived neurotrophic factor may exert as anorexigenic factors possibly through the activation of tyrosine kinase receptor B in the ventromedial hypothalamic nucleus and dorsomedial hypothalamic nucleus. | lld:pubmed |
| pubmed-article:16564638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16564638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16564638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16564638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16564638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16564638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16564638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16564638 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:16564638 | pubmed:author | pubmed-author:MorikawaYY | lld:pubmed |
| pubmed-article:16564638 | pubmed:author | pubmed-author:SenbaEE | lld:pubmed |
| pubmed-article:16564638 | pubmed:author | pubmed-author:NanjoKK | lld:pubmed |
| pubmed-article:16564638 | pubmed:author | pubmed-author:KomoriTT | lld:pubmed |
| pubmed-article:16564638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16564638 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:16564638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16564638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16564638 | pubmed:pagination | 1107-15 | lld:pubmed |
| pubmed-article:16564638 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16564638 | pubmed:meshHeading | pubmed-meshheading:16564638... | lld:pubmed |
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| pubmed-article:16564638 | pubmed:meshHeading | pubmed-meshheading:16564638... | lld:pubmed |
| pubmed-article:16564638 | pubmed:meshHeading | pubmed-meshheading:16564638... | lld:pubmed |
| pubmed-article:16564638 | pubmed:meshHeading | pubmed-meshheading:16564638... | lld:pubmed |
| pubmed-article:16564638 | pubmed:meshHeading | pubmed-meshheading:16564638... | lld:pubmed |
| pubmed-article:16564638 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16564638 | pubmed:articleTitle | Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. | lld:pubmed |
| pubmed-article:16564638 | pubmed:affiliation | Department of Anatomy and Neurobiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan. | lld:pubmed |
| pubmed-article:16564638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16564638 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16564638 | lld:pubmed |
