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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-3-22
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pubmed:abstractText |
Since the identification of BRCA1 and BRCA2, there has been no major breast cancer susceptibility gene discovered by linkage analysis in breast cancer families. This has been attributed to the heterogeneous genetic basis for the families under study. Recent studies have indicated that breast tumors arising in women carrying a BRCA1 mutation have distinct histopathologic, immunophenotypic, and genetic features. To a lesser extent, this is also true for breast tumors from BRCA2 carriers. This indicates that it might be possible to decrease the genetic heterogeneity among families in which BRCA1 and BRCA2 have been excluded with high certainty (BRCAx families) if distinct subgroups of BRCAx-related breast tumors could be identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:Cleton-JansenAnne-MarieAM,
pubmed-author:CornelisseCees JCJ,
pubmed-author:DevileePeterP,
pubmed-author:HoogerbruggeNicolineN,
pubmed-author:Houwing-DuistermaatJeanine JJJ,
pubmed-author:KraanJaennelleJ,
pubmed-author:Kroeze-JansemaKarinK,
pubmed-author:Meijers-HeijboerHanneH,
pubmed-author:MorreauHansH,
pubmed-author:OldenburgRogier ARA,
pubmed-author:VasenHans F AHF,
pubmed-author:van AsperenCristi JCJ,
pubmed-author:van LeeuwenIngeI
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1693-700
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16551851-Adult,
pubmed-meshheading:16551851-Aged,
pubmed-meshheading:16551851-Aged, 80 and over,
pubmed-meshheading:16551851-BRCA1 Protein,
pubmed-meshheading:16551851-BRCA2 Protein,
pubmed-meshheading:16551851-Breast Neoplasms,
pubmed-meshheading:16551851-Chromosomes, Human, Pair 22,
pubmed-meshheading:16551851-Cluster Analysis,
pubmed-meshheading:16551851-Family Health,
pubmed-meshheading:16551851-Female,
pubmed-meshheading:16551851-Genetic Linkage,
pubmed-meshheading:16551851-Genome, Human,
pubmed-meshheading:16551851-Humans,
pubmed-meshheading:16551851-Immunohistochemistry,
pubmed-meshheading:16551851-Lod Score,
pubmed-meshheading:16551851-Loss of Heterozygosity,
pubmed-meshheading:16551851-Microsatellite Repeats,
pubmed-meshheading:16551851-Middle Aged,
pubmed-meshheading:16551851-Receptors, Estrogen,
pubmed-meshheading:16551851-Receptors, Progesterone,
pubmed-meshheading:16551851-Tumor Markers, Biological,
pubmed-meshheading:16551851-Tumor Suppressor Protein p53
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pubmed:year |
2006
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pubmed:articleTitle |
Characterization of familial non-BRCA1/2 breast tumors by loss of heterozygosity and immunophenotyping.
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pubmed:affiliation |
Center for Human and Clinical Genetics, Department of Pathology, Leiden University Medical Center, Rotterdam, the Netherlands. R.A.Oldenburg@lumc.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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