| pubmed-article:16542002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0007585 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0040077 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C0206795 | lld:lifeskim |
| pubmed-article:16542002 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:16542002 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16542002 | pubmed:dateCreated | 2006-3-17 | lld:pubmed |
| pubmed-article:16542002 | pubmed:abstractText | Thymidine (Thd), 1-beta-D-arabinosylthymine (ara-T) and 3'-fluoro-3'-deoxythymidine (FLT) have been substituted at N-3 by a methyl or a 2-fluoroethyl group. FLT and ara-T are markedly inhibitory against human immunodeficiency virus type 1 (HIV-1) and HIV-2, and herpes simplex virus type 1 (HSV-1) and HSV-2, respectively. Modification at N-3 of these compounds markedly decreases both the antiviral and cytostatic activity of the parent compounds FLT and ara-T except for N-3-(methyl)-Thd that proved highly cytostatic for murine leukaemia L1210 cells. The decreased biological activity of the N-3-substituted pyrimidine nucleoside analogues coincides with a significantly lower affinity of the modified Thd analogues for the cellular and viral (activating) nucleoside kinases. | lld:pubmed |
| pubmed-article:16542002 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16542002 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16542002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16542002 | pubmed:issn | 0956-3202 | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:BalzariniJanJ | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:BormansGuyG | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:VerbruggenAlf... | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:KarlssonAnnaA | lld:pubmed |
| pubmed-article:16542002 | pubmed:author | pubmed-author:CelenSofieS | lld:pubmed |
| pubmed-article:16542002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16542002 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16542002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16542002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16542002 | pubmed:pagination | 17-23 | lld:pubmed |
| pubmed-article:16542002 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16542002 | pubmed:meshHeading | pubmed-meshheading:16542002... | lld:pubmed |
| pubmed-article:16542002 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16542002 | pubmed:articleTitle | The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture. | lld:pubmed |
| pubmed-article:16542002 | pubmed:affiliation | Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium. jan.balzarini@rega.kuleuven.be | lld:pubmed |
| pubmed-article:16542002 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16542002 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
