Previous studies showed that nerve growth factor (NGF) induces the expression of functional FSH receptors (FSHR) in preantral follicles of the developing rat ovary.
Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion.
Laboratorio de Endocrinología y Biología Reproductiva, Departamento Obstetricia y Ginecología, Facultad de Medicina, Hospital Clinico J. J. Aguirre, Universidad de Chile, Santos Dumont 999 Independencia, Santiago 838-0456, Chile.