| pubmed-article:16530704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C0685938 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C2755352 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C2348867 | lld:lifeskim |
| pubmed-article:16530704 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:16530704 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16530704 | pubmed:dateCreated | 2006-3-13 | lld:pubmed |
| pubmed-article:16530704 | pubmed:abstractText | We studied the relationships between genetic and epigenetic alterations in gastrointestinal cancer by integrating DNA copy number changes determined by arbitrarily primed PCR (AP-PCR) with DNA methylation variations estimated by methylation-sensitive amplified fragment length polymorphism (MS-AFLP). We analyzed about 100 different chromosomal regions by AP-PCR and over 150 random CpG loci by MS-AFLP in human colon and gastric carcinomas. DNA hypomethylation and hypermethylation alterations distributed gradually and increased with cancer patient age, in contrast with the age-independent genomic alterations. Increased DNA hypomethylation and hypermethylation correlated with increased genomic damage, but only hypomethylation was highly significant in multivariate analyses. We conclude that age-dependent accumulation of DNA demethylation precedes diploidy loss in a significant subset of gastrointestinal cancers. | lld:pubmed |
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| pubmed-article:16530704 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16530704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16530704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16530704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16530704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16530704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16530704 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16530704 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:SuzukiKoichiK | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:HoriuchiShina... | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:LeodolterAndr... | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:SuzukiIkukoI | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:YamashitaKent... | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:PeruchoManuel... | lld:pubmed |
| pubmed-article:16530704 | pubmed:author | pubmed-author:AlonsoSergioS | lld:pubmed |
| pubmed-article:16530704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16530704 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:16530704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16530704 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16530704 | pubmed:pagination | 199-207 | lld:pubmed |
| pubmed-article:16530704 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:16530704 | pubmed:meshHeading | pubmed-meshheading:16530704... | lld:pubmed |
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| pubmed-article:16530704 | pubmed:meshHeading | pubmed-meshheading:16530704... | lld:pubmed |
| pubmed-article:16530704 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16530704 | pubmed:articleTitle | Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. | lld:pubmed |
| pubmed-article:16530704 | pubmed:affiliation | Burnham Institute for Medical Research, Cancer Genetics and Epigenetics Research Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. | lld:pubmed |
| pubmed-article:16530704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16530704 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16530704 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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