| pubmed-article:16517407 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C1704332 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C1825620 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C0005495 | lld:lifeskim |
| pubmed-article:16517407 | lifeskim:mentions | umls-concept:C1156273 | lld:lifeskim |
| pubmed-article:16517407 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16517407 | pubmed:dateCreated | 2006-3-6 | lld:pubmed |
| pubmed-article:16517407 | pubmed:abstractText | Iron-sulfur (Fe-S) clusters are required for the functions of mitochondrial aconitase, mammalian iron regulatory protein 1, and many other proteins in multiple subcellular compartments. Recent studies in Saccharomyces cerevisiae indicated that Fe-S cluster biogenesis also has an important role in mitochondrial iron homeostasis. Here we report the functional analysis of the mitochondrial and cytosolic isoforms of the human Fe-S cluster scaffold protein, ISCU. Suppression of human ISCU by RNAi not only inactivated mitochondrial and cytosolic aconitases in a compartment-specific manner but also inappropriately activated the iron regulatory proteins and disrupted intracellular iron homeostasis. Furthermore, endogenous ISCU levels were suppressed by iron deprivation. These results provide evidence for a coordinated response to iron deficiency that includes activation of iron uptake, redistribution of intracellular iron, and decreased utilization of iron in Fe-S proteins. | lld:pubmed |
| pubmed-article:16517407 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16517407 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517407 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16517407 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16517407 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16517407 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16517407 | pubmed:issn | 1550-4131 | lld:pubmed |
| pubmed-article:16517407 | pubmed:author | pubmed-author:RouaultTracey... | lld:pubmed |
| pubmed-article:16517407 | pubmed:author | pubmed-author:TongWing-Hang... | lld:pubmed |
| pubmed-article:16517407 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16517407 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:16517407 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16517407 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16517407 | pubmed:pagination | 199-210 | lld:pubmed |
| pubmed-article:16517407 | pubmed:dateRevised | 2007-7-25 | lld:pubmed |
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| pubmed-article:16517407 | pubmed:meshHeading | pubmed-meshheading:16517407... | lld:pubmed |
| pubmed-article:16517407 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16517407 | pubmed:articleTitle | Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. | lld:pubmed |
| pubmed-article:16517407 | pubmed:affiliation | National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:16517407 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16517407 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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