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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-4-3
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pubmed:abstractText |
A novel series of achiral TNF-alpha converting enzyme (TACE) inhibitors has been discovered. These compounds exhibited activities from 0.35 to 11nM in a porcine TACE assay and inhibited TNF-alpha production in an LPS-stimulated whole blood assay with an IC(50) value of 23nM for the most potent one. They also have excellent selectivities over related metalloproteases including aggrecanases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:CovingtonMaryanne BMB,
pubmed-author:DeciccoCarl PCP,
pubmed-author:DuanJames J-WJJ,
pubmed-author:GilmoreJohn LJL,
pubmed-author:HarrisCathyC,
pubmed-author:KingBryan WBW,
pubmed-author:LiuRui-QinRQ,
pubmed-author:MaduskuieThomasT,
pubmed-author:MercerStephen ESE,
pubmed-author:NewtonRobert CRC,
pubmed-author:QianMingxinM,
pubmed-author:RibadeneriaMaria DMD,
pubmed-author:TrzaskosJames MJM,
pubmed-author:VaddiKrishnaK
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2699-704
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. john.gilmore@bms.com
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pubmed:publicationType |
Journal Article
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