|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-2-21
|
|
pubmed:abstractText |
Interferons (IFNs) have antiproliferative effects on tumor cells. The apoptotic effects and sensitization to chemotherapy conferred by IFN therapy, however, are not clearly understood. The aims of the present study were to explore the apoptotic effects of IFNs in human pancreatic cancer cell lines and to attempt to define their ability to synergistically enhance sensitivity to 5-fluorouracil (5-FU) and gemcitabine, a mechanism that depends on the expression of IFN receptors.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0002-9610
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
191
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
358-63
|
|
pubmed:dateRevised |
2006-4-24
|
|
pubmed:meshHeading |
pubmed-meshheading:16490547-Antineoplastic Agents,
pubmed-meshheading:16490547-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16490547-Apoptosis,
pubmed-meshheading:16490547-Caspases,
pubmed-meshheading:16490547-Cell Line, Tumor,
pubmed-meshheading:16490547-Deoxycytidine,
pubmed-meshheading:16490547-Drug Synergism,
pubmed-meshheading:16490547-Fluorouracil,
pubmed-meshheading:16490547-Humans,
pubmed-meshheading:16490547-Interferons,
pubmed-meshheading:16490547-Pancreatic Neoplasms,
pubmed-meshheading:16490547-Receptors, Interferon
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Interferon receptors and the caspase cascade regulate the antitumor effects of interferons on human pancreatic cancer cell lines.
|
|
pubmed:affiliation |
Department of Surgery, Providence Hospital and Medical Centers, 22250 Providence Drive, Suite 700, Southfield, MI 48075, USA.
|
|
pubmed:publicationType |
Journal Article,
Evaluation Studies
|
