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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-7-23
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pubmed:abstractText |
'Mammary-derived growth inhibitor (MDGI)' is a 14.5 kDa polypeptide with growth-inhibitory activity for various mammary epithelial cells in vitro which is highly homologous to cardiac fatty acid-binding protein (H-FABP). Here we describe a new biological activity of MDGI: Inhibition of L(+)-lactate-, arachidonic acid- and 15-S-hydroxyeicosatetraenoic acid-induced supersensitivity of neonatal rat heart cells for beta-adrenergic stimulation, concerning particularly a small population of beta 2-receptors. Synthetic peptides corresponding to the MDGI-sequence, residue 121-131 mimic the effect of MDGI. Measurements of lipid-binding to MDGI and synthetic peptides excluded the binding of arachidonic acid, 15-S-hydroxyeicosatetraenoic acid or beta-adrenergic agonists to MDGI or the peptides as the mechanism for this effect. Also, no direct interference of MDGI and the synthetic peptides with the binding of the beta-adrenergic agent CGP 12177 to its receptor on A431 cells could be detected. We suggest that MDGI and the peptides act by interference with the function of the beta 2-adrenergic receptor and that this mechanism might also be relevant for the growth-inhibitory activity of MDGI. Furthermore, the data point to a possible function of H-FABP for the modulation of beta-adrenergic sensitivity of cardiac myocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 12177,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fabp7 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Lactates,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Propanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins D,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0300-8177
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-60
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pubmed:dateRevised |
2006-11-20
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pubmed:meshHeading |
pubmed-meshheading:1646956-Amino Acid Sequence,
pubmed-meshheading:1646956-Animals,
pubmed-meshheading:1646956-Arachidonic Acid,
pubmed-meshheading:1646956-Arachidonic Acids,
pubmed-meshheading:1646956-Binding, Competitive,
pubmed-meshheading:1646956-Carrier Proteins,
pubmed-meshheading:1646956-Dose-Response Relationship, Drug,
pubmed-meshheading:1646956-Fatty Acid-Binding Proteins,
pubmed-meshheading:1646956-Growth Inhibitors,
pubmed-meshheading:1646956-Heart,
pubmed-meshheading:1646956-Isoproterenol,
pubmed-meshheading:1646956-Lactates,
pubmed-meshheading:1646956-Molecular Sequence Data,
pubmed-meshheading:1646956-Neoplasm Proteins,
pubmed-meshheading:1646956-Nerve Tissue Proteins,
pubmed-meshheading:1646956-Peptides,
pubmed-meshheading:1646956-Propanolamines,
pubmed-meshheading:1646956-Prostaglandins D,
pubmed-meshheading:1646956-Rats,
pubmed-meshheading:1646956-Receptors, Adrenergic, beta
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pubmed:year |
1991
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pubmed:articleTitle |
Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI.
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pubmed:affiliation |
Central Institute for Cardiovascular Research, Academy of Sciences, Berlin-Buch, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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